Carbon fiber reinforced polyether-ether-ketone (CF/PEEK) composite materials had a wide range of applicationsin the aerospace, electronics and electrical fields, etc. The composite materials were generally prepared from prepregs. Commonly used prepreg tape preparation methods had disadvantages of uneven resin distribution and inadequate fiberimpregnation, resulting in high porosity and poor mechanical properties. In this research, a combined process of the doublepowder impregnation method and the melt homogenization method was used to prepare the CF/PEEK prepreg tape to solvethe previous problems. Using this method, the porosity of the prepreg tape was reduced by 56.30 % and the tensile strengthwas increased by 43.35 % compared with the traditional powder impregnation method. At the same time, the prepreg tapewas widened and thinned and the uniformity of resin distribution was improved. Besides, based on the single factorexperiment, the response surface method was used to construct the impregnation model of the quadratic polynomialregression equation between the process parameters (powder impregnation temperature, traction speed and melthomogenization temperature) and the porosity of the CF/PEEK prepreg tape. According to this model, the process parametersfor the porosity of the prepreg tape were calculated to reach the minimum, namely, the powder impregnation temperature was380 ℃, the traction speed was 1 m/min, and the melt homogenization temperature was 380 ℃. As a result of these processparameters, the porosity of the prepreg tape could be reduced to 7.39 %. Subsequently, the model was verified throughexperiments, which could provide a reference for the process parameters setting of the impregnation process.