The high cost and narrow detection range of electrocatalyst are the two major challenges for the electrochemicalbiosensors. This work provided a surfactant-free synthesis of CuBr@Pt nanoparticles (CuBr@PtNPs) with controllable Pt loading rates. The introduction of chloroplatinic acid (H2PtCl6) and an elevatedsynthesis temperature resulted in a high surface area for CuBr@Pt NPs. The abundant active sites enabledthe CuBr@Pt NPs a superior performance as applied in glucose and nitrite detection. Moreover, an optimalPt loading would be conducive to optimize sensor performances of CuBr@Pt NPs. In the glucose detection,the sensor by CuBr@Pt-15% could reach the detection concentration up to 68.0 mM, which was 1.9 timeshigher than that by pure CuBr. And the corresponding sensitivity by CuBr@Pt-15% was calculated to be382.73 lA/mMcm2. In the detection of sodium nitrite, CuBr@Pt-15% also revealed a superior behaviorthan previous work. And the detection concentration (by the linear sweep voltammetry) was form 0 to80.0 mM. This work demonstrated the superior biosensor performance of CuBr@Pt-15%, which offereda promising material for sensor with wider detection range and rationalized cost.