The families of MAX phases and their derivatives MXenes are constantly increasing in terms of bothcomposition and crystalline mixtures. In the last three years, numerous advances were accomplishedthat improved the preparation of new MAX phases with prearranged double transition metals and, as aresult, the production of novel MXenes with a high structural complexity and chemical multiplicity,infrequently observed in other families of two-dimensional samples. In this evaluation, hybrids ofMXenes and semiconductors are efficient photocatalysts, because of their specific interface character-istics and Schottky heterojunction is capable of giving accelerated charge separation and a lowerSchottky barrier for photocatalytic applications. The latest advances were proved that the MXenessupported semiconductors based photocatalysts can be expected as the most advantaged andencouraged novel photocatalysts in the photocatalytic and photoelectrochemical applications. Besides,we have explained significant developments in efficient MXenes supported semiconductors basednanocomposites, including the frequent synthesis strategies and progress mechanisms, in addition totheir new applications including, photodegradation of dyes, CO2 conversion, photocatalytic andphotoelectrochemical water splitting reaction applications. The review was completed with a shortpresentation of future challenges and prospects in the progress of MXenes supported semiconductorsbased photocatalysts. It is also believed that this review will encourage further exploration and willinaugurate new promising to increase new MXenes supported semiconductors based photocatalystswith new and inspiring applications.