In the electro-Fenton system, designing a low-cost and efficient 2e oxygen-reducing cathode materialsis critical for pollutants of degradation. In this work, we proposed a hydrophilic graphite felt gas diffusioncathode modified by acetylene black/PTFE under slow-drying mechanism to degrade norfloxacin (NOR). The results showed that the graphite felt gas diffusion cathode in slow drying mode had better curingeffect due to weak capillarity and formed more 3-phase interfaces compared with the traditionalquick-drying way, which was conducive to locally confined O2 storage and transfer. The slow-dryingmethod had more H2O2 yield and efficient NOR removal rate. It was found that 30 mg/L NOR achieved92.2 % degradation and almost 71.3 % of NOR was completely mineralized within 120 min under optimalreaction conditions. Interestingly, the H2O2 yield was only decreased by 5.2 % after 10 cycles, and the NORremoval rate decreased 3.8 % after pickling, which exerted an excellent reusability. The radicals quenchingexperiments revealed that OH and O2were the main active species in NOR degradation process. Besides, it was found that PTFE coating was not beneficial for the activation of H2O2 by graphite structure. Finally, possible NOR degradation pathways were proposed by Ultra performance liquidchromatography-mass spectrometry (LC-MS).