Acetaminophen (ACT) is an effective and widely available analgesic and antipyretic used in medical practice. It can get into water from veterinary use, medical waste and pharmaceutical effluents. The aim ofthis review was to elaborate on the recent progress on ACT adsorption from water, present the findingsin a structured written report and identify interesting new foundations for further work. ZnAl/biocharhad the highest potential of removing ACT and can adsorb more than its weight of the pollutant(qmax > 1000 mg/g). The Langmuir and Freundlich isotherm models and the pseudo-second-order kineticsmodel were best-fits in most cases (usually at R2 > 0.99 threshold). It was observed that the key mechanismsof ACT uptake are p-p interactions, hydrogen bonds and electrostatic interaction. For most of theadsorbents, a >30% ACT removal efficiency was achievable after the 4 cycles. Effects as salting-out, electrostaticscreening, and accumulation of moieties at sorbent-sorbate interfaces due to the competitiveadsorption of ions and co-pollutants are profound in the uptake of ACT from aqueous solutions. Futureperspectives were discussed in the area of process costing, adsorbent regeneration, mechanistic investigationsand fixed-bed column adsorption.