Ultraviolet radiation is extremely harmful to humans and often occurs in high-temperature weather. Thedevelopment of intelligent textiles based on UV protection and thermal regulation is paramount. In thisresearch, we use coaxial electrospinning technology to prepare anti-ultraviolet smart thermo-regulatingnanofiber membranes. The zinc oxide (ZnO) and octadecane were incorporated into nanofibers with thepolyacrylonitrile (PAN)/ZnO as sheath and the octadecane as core successfully. The composite nanofibershave excellent comprehensive properties, the highest melting enthalpy is 111.38 J/g, and the UPF value is86.21. This multifunctional nanofiber membrane has broad prospects in outdoor products, electroniccomponent protection, and military products.