The ferric ions sludge produced during pollutants degradation was an obstacle for large scale application of Fentonoxidation technology. Herein, we reported a facile method using 2,2,6,6-tetramethylpiperidine-1-oxygen radical (TEMPO)-oxidized cotton fabric as a substrate for anchoring Fe(II) ions to produce Fe(II)-anchored cotton fabric. The formation ofFe(II)-anchored cotton fabric was confirmed using EDS analysis and FTIR measurement. Bath experiments indicated thatFe(II)-anchored cotton fabric could Fenton oxidize rhodamine B (RhB) dye in a high efficient rate (95.9 %) within 60 minwithout second pollution. Fe(II)-anchored cotton could be reused without any physical/chemical treatment and itsdecolorization efficiency was retained at 89.9 % even after the third cycle. Moreover, the decolorization behavior of Fe(II)-anchored cotton fabric for the RhB solution was affected by H2O2 dosage, Fe(II) ion content, and inorganic salts. Kineticstudy indicated that the RhB decolorization process fits a pseudo-first order well and the sorption isotherm assessmentrevealed that the reactive sorption of RhB dye on Fe(II)-anchored cotton fabric fits the Freundlich model.