Three new neolignans, fordianoles A-C (1–3),characterized as (7S,8R)-4-hydroxy-3,30,50-trimethoxy-80,90-dinor-8,40-oxyneolignan-7,70,9-triol, (7R,8R)-4-hydroxy-3,30,50-trimethoxy-80,90-dinor-8,40-oxyneolignan-7,70,9-triol, and (7R,8R)-4-hydroxy-3,30,50-trimethoxy-8,40-oxyneolignan-7,9,90-triol-70-one, together with an unusual c-lactone,3-(3,4-dihydroxyphenyl)-4-pentanolide (4), andtwenty-five known compounds (5–29) were isolated fromthe aerial parts of Viburnum fordiae Hance. Their structuresincluding absolute configurations were determined byspectroscopic and chemical methods. Among them, compounds6, 7, 11–15, 17–28 were isolated from the Viburnumgenus for the first time. The anti-inflammatory and antioxidantactivities of all compounds were evaluated in vitro. Compounds 15, 19, 20 and 29 showed significant inhibitoryactivity on NO production in RAW264.7 cells stimulated byLPS with IC50 values ranging from 8.60 to 13.92 lM. Meanwhile, compounds 1–4, 15, 19, 20, 22, 23, 25, 26 and29 exhibited varying antioxidant activities through DPPH,ABTS free radical scavenging and FRAP assays.