Sea sand vanadia-titania magnetite is difficult to pelletize, and it is difficult for iron and steel enterprises touse it as a raw material for ironmaking. In this paper, the high-temperature physicochemical characteristics and sinteringbehavior of sea sand vanadia-titania magnetite were comprehensively studied and systematically evaluated. Thehigh-temperature metallurgical physicochemical characteristics of different iron ore powders and under different experimentalconditions were studied by the micro-sintering experimental system. The high-temperature sintering indexeswere comprehensively evaluated by the grey correlation analysis, and the influence of sea sand ore on sintering performancewas investigated by sintering pot experiment. The research results show that the high-temperature sinteringcharacteristics of sea sand vanadia-titania magnetite were the worst, and the grey correlation degree was the lowest. The high-temperature sintering characteristics of sintered blocks with sea sand ore were affected by changing the basicityand the addition amount of sea sand ore. When the basicity was 0.8 and the addition amount of sea sand ore was15 wt%, the evaluation index of grey relational analysis was the best. The vertical sintering speed and tumble indexwere slightly reduced by adding sea sand ore, but the sinter yield was improved and the particle size distribution of sinterwas optimized. The experimental results provide a certain data reference for the actual production of sinter with seasand vanadia-titania magnetite.