Background Perforator artery flaps based on the branches of intercostal arteries and lateralthoracic artery can be used for reconstruction after breast-conserving surgery (BCS). Althoughdescribed more than a decade ago, these have not been adopted widely in clinicalpractice. We report on short-term and long-term surgical outcomes of partial breast reconstructionusing chest wall perforator flaps from a prospective multicenter audit. Methods All patients operated for BCS and partial breast reconstruction using intercostalartery perforator or lateral thoracic artery perforator flaps from January 2015 to October2018 were included in the analysis. Oncoplastic breast surgeons with appropriate level oftraining performed all tumor excisions and reconstructions as a single-stage procedure. Patientcharacteristics, treatment details and surgical outcomes were noted. Specific outcomesrecorded were margin re-excision and complication rates. Results One hundred and twelve patients underwent the procedure in the given study period. The median age was 54 years. Median specimen weight was 62.5 g and median volume of excisionwas 121.4 mL. Fifteen patients (13.39%) underwent a margin re-excision for close orpositive margins without additional morbidity. One patient required a completion mastectomy. Eight patients (7.14%) had an early complication. None of the patients required a contralateralsymmetrization procedure. The results were comparable across the participating centers. Conclusions Chest wall artery perforator-based flaps are an excellent option for lateral andinferior quadrant partial breast reconstructions. The short and long-term surgical outcomesare comparable across sites and can be performed with minimal morbidity. Patient-reportedoutcome measures need to be studied.