This research aims to assess the behavior of reinforced concrete (RC) residential buildings when moment-resisting frames (MRFs) are used as the lateral resisting system. This investigation was conducted using MIDAS Gen v.19.0. Buildings with various plan footprints (Square, Rectangular, Circular, Triangular, and Plus-Shaped), and different heights (15 m, 30 m, 45 m, and 60 m) are investigated. The defined load cases, the equivalent static lateral load pattern, and the response spectrum function were defined as stated by the American Standard (ASCE 7-16), the 1997 Uniform Building Code (UBC97), the Egyptian Code for Loads (ECP-201), and the European Standard (EC8). Extensive comparisons of the results obtained by the different codes (including the story displacement, the story drift, and the base shear) were undertaken; to assess the response of moment-resisting multi-story framed buildings under lateral loads. The results revealed that, for all study cases under consideration, both ECP-201 and EC8 gave smaller base shear, displacement, and drift by one third to one fourth, around one fourth, around one fifth, respectively for both the ELF and RSA methods if compared to ASCE 7-16 and UBC97.