Old women showed a different specificity of body composition compared to middle-aged women. This study analyzed the age-related differences of body composition, metabolic risk factors, physical fitness, and the relationship among their items. Subjects consisted 62 women (the 40s group n=32; the 60s group n=30), and items were measured body composition, blood lipid profiles and inflammatory markers, blood pressure, abdominal fat area, intima-media thickness of carotid artery, and physical fitness. The 60s group showed a significant higher values of WHR, blood concentration of IL-6, and intima-media thickness as compared to the 40s group. The 40s showed a significant relationship among body weight, BMI, BP, blood lipid profiles and inflammatory markers, however the 60s showed no significant relationship among their variables. But visceral fat area of the 60s group showed a significant relationship with circulating inflammatory markers and insulin resistance. Therefore the negative association of body wight and body fat with metabolic syndrome and vascular inflammation showed to be obscure for the 60s group, and they should try to prevent the increase of visceral fat.