We studied the acute effects of a core exercise machine on glucose metabolism using the euglycemic glucose clamp technique. The subjects were 9 healthy adults (3 men, 6 women). The glucose infusion rate (GIR) significantly increased during 30 minutes of exercise (p<0.05), after which the rate decreased at recovery time. These results suggest that the use of a core exercise machine led to increased energy expenditure and the enhanced uptake of glucose in the skeletal muscles, especially the abdomen, thigh, and core muscles.