In this study, the collision experiments to retaining wall with the base-isolated building model whose superstructure was designed to yield upon collision and the simulation analysis were conducted. The analysis captured the trend of the experimental acceleration response well, and the strains were comparable to the experimental results. In addition, the collision analyses were conducted on a full-scale base-isolated building with the parameters of superstructure strength and damping performance. As the superstructure strength was increased, the deformation of superstructure was smaller, but the acceleration was larger. On the other hand, as the damping performance was increased, both responses were smaller.