We herein describe a 57-year-old man with a history of foot amputation due to right foot necrosis as a complication of type 2 diabetes. The patient was admitted with fever and difficulty moving. Pyogenic spondylitis was suspected due to heat sensation and tenderness near the 5th lumbar vertebra and a high inflammatory response. The patient was first administered tazobactam/piperacillin. On the 4th day, a combination of vancomycin and meropenem was administered. A blood culture was positive for methicillin-resistant Staphylococcus aureus (MRSA), and the trough level was within the recommended range. The patient was diagnosed with acute renal failure based on edema, oliguria, and increased serum Cron day 10, and vancomycin was discontinued. Although treatment was changed to Sulfamethoxazole Trimethoprim (ST) compound, it was discontinued due to the development of a high fever and neutropenia. Linezolid was subsequently initiated. The patient was hospitalized for a long time and continued treatment in the medical care ward. After stopping linezolid, minomycin and rifampicin were co- administered. With strict blood sugar control, a complete cure was achieved after 105 days. This patient developed purulent spondylitis at a difficult-to-operate site and, thus, was not indicated for surgery and transferal to another hospital was not possible.