Crystal Structure Analysis of the 20S Proteasome Grown in Space: Comparison between Space and Ground Crystals
- Resource Type
- Journal Article
- Authors
- Koji INAKA; Masayuki KAMO; Naoki FURUBAYASHI; Yukio MORIMOTO; Yuuki HIGASHINO
- Source
- International Journal of Microgravity Science and Application. 2020, 37(4):370404
- Subject
- Anti-cancer drug
Inhibitor complex
Mosaicity
Proteasome
- Language
- English
- ISSN
- 2188-9783
Microgravity utilization in space is a powerful technique for high-quality protein crystallization. Drug design requires information regarding three-dimensional atomic coordinates from a precious protein structure at atomic resolution. Crystals obtained in space have greater availability for the analysis of drug/protein interactions compared to crystals on the ground. In this study, we assessed the reliabilities of crystal characterization based on the mosaicities of the space and ground crystals and determined a complex whole structure of the 20S proteasome with an anticancer drug.