Tumor necrosis factor (TNF) receptor superfamily members transmit signals that promote diverse cellular responses. Cell growth, differentiation, migration, and apoptosis are regulated by growth factors or cytokines which exert their effects via ligand-induced dimerization or trimerization of cell surface receptors. Abnormalities in such signal transduction pathways cause for pathological conditions and diseases such as arthritis, cancer, AIDS and diabetes. To study ligand-induced activation of TNF receptor superfamily as well as subsequent downstream effects, we tried to design and synthesis compound to be capable of trimerizing GST-fused signal transducing protein. We report herein synthesis of novel compounds in which three glutathione appendages are symmetrically placed around the central benzene, assembling GST-fused proteins.