The mechanism of elimination of the oxidized nucleotides in Caenorhabditis elegans / 線虫C. elegansにおける酸化ヌクレオチド分解機構
- Resource Type
- Journal Article
- Authors
- U SANADA; 真田 悠生
- Source
- The Japan Radiation Research Society Annual Meeting Abstracts. 2011, :64
- Subject
- NDX
nucleotide pool
oxidative damage
ヌクレオチドプール
酸化損傷
- Language
- Japanese
Oxidative DNA damage occurs directly in DNA and in nucleotides (dNTPs) in the nucleotide pool. Oxidized nucleotides such as 8-oxo-dGTP or 2-OH-dATP could be incorporated into DNA during replication, which could result in mutagenic consequences. Many organisms have enzymes for eliminating the abnormal nucleotides in the nucleotide pool as well as repair enzymes for damage in DNA. In this study, we have identified enzymes involved in sanitization of the nucleotide pool in C. elegans and analyzed the RNAi phenotypes of C. elegans under environmental stress. Together with our recent observations, we will introduce the mechanism of elimination of the oxidized nucleotides in C. elegans.