The findings of vascular endothelial function tests have attracted attention as surrogate markers for cardiovascular disease prevention in patients with type 2 diabetes. The flow-mediated dilation (FMD) and reactive hyperemia index (RHI) were measured at the same time in 106 patients with type 2 diabetes. In a univariate analysis, the FMD was significantly positively correlated with the estimated glomerular filtration rate (eGFR) and significantly negatively correlated with age, urinary albumin-to-creatinine ratio (ACR), systolic blood pressure, brachial-ankle pulse wave velocity (baPWV) and carotid intima-media thickness (IMT). The RHI was significantly positively correlated with ABI and significantly negatively correlated with the ABI and carotid IMT. Student's t-test showed that the FMD was significantly lower in diabetic patients who were male or suffering from nephropathy than in others and that the RHI was significantly lower in those who were smokers or being treated with statins than in others. In a multiple regression analysis, the FMD was associated with gender, eGFR and baPWV, while the RHI was associated with the ABI, carotid IMT and treatment with statins. The clinical parameters for cardiovascular disease that were associated with the FMD differed from those associated with the RHI, and the FMD was not significantly correlated with the RHI.