Single needle‒hemodialysis(SN‒HD) with a puncture needle is sometimes performed in cases in which it is difficult to puncture the blood return side and for self‒puncturing during home dialysis, but it is also indicated for cases in which high dialysis efficiency is not required. We hypothesized that there might be some scenarios in which performing SN‒HD using a single‒lumen catheter(SLC) would also be effective. However, as it was unclear how much dialysis efficiency decreases when SN‒HD is performed using a SLC, we studied the optimal conditions for maximizing dialysis efficiency so that this technique could be used in a wide range of patients. The blood flow volume for the study was fixed at 300 mL/min, and 11 directions in which the pressure could be switched were set. The amount of movement and recirculation rate of simulated blood were measured for ten minutes, after which the actual processed amount was calculated. As a result, the actual processing rate at the default pressure for switching(200/100 mmHg) was found to be approximately 104 mL/min, while the highest processing rate seen was 130 mL/min at a pressure of 300/150 mmHg. This study revealed the optimal conditions for performing SN‒HD using a SLC, which could result in greater dialysis efficiency than is produced by the default conditions.