We herein report our clinical experience in continuous flow peritoneal dialysis (CFPD) using two catheters in an anuric preterm baby with severe respiratory disturbance due to oligohydramnios. The method proved efficacious in removing solute and water without worsening respiratory status. The patient is a 10-month-old girl at present in whom oligohydramnios had been pointed out at 26 weeks of gestation. She was born at 33 weeks of gestation weighing 1862g, and required assisted ventilation for pulmonary hypoplasia. She also needed inhaled nitric oxide therapy for persistent pulmonary hypertension of the newborn. CFPD was started on day 3 for anuria, and was effective for correction of fluid and electrolytes imbalance. It did not interfere with respiratory control, so that she could be extubated on day 10. Complications with CFPD did arise in the follow-up course, such as occlusion of the drain catheter with omentum, bacterial peritonitis and catheter leak. Despite these complications requiring transient cessation of dialysis and revision of the peritoneal catheter, she is currently well under regular automated peritoneal dialysis with one catheter.CFPD does not depend upon dwelling as dialysate only passes through the peritoneal cavity. This may be of great advantage when applied to newborn patients whose respiration and circulation may be critically affected by rises in abdominal pressure. To establish this procedure, prevention of the complications as seen in our case is indispensable. Especially, it should be noted that this system does not equip any monitoring device to detect drainage failure. When drainage failure occurs pump-forced inflow would continue regardless of the residual volume in the peritoneal cavity, resulting in the rise of abdominal pressure more easily than standard one-catheter CAPD. Therefore careful monitoring of dialysate flow as well as tight fixing of catheter cuffs is necessary to avoid leakage.