Results: This study enrolled consecutive 489 patients with 595 lesions undergoing DCB treatment. The median MLA (interquartile range) was 13.20 (9.90–16.91) mm2. Kaplan–Meier estimates showed that freedom from restenosis was 84.4% at 1 year. The GPS-adjusted dose–response function showed that MLA was inversely associated with restenosis risk. The upper limit of 95% confidence interval (CI) of the slope was lower than 0 between 10.6 and 17.0 mm2 of MLAs. The 1-year cumulative incidence of restenosis was estimated to be 9.8% (95% CI, 5.8%–13.7%) for the 3rd quartile of MLA (16.91 mm2) versus 18.5% (12.3%–24.1%) for the 1st quartile (9.90 mm2), with a hazard ratio of 0.51 (95% CI, 0.39–0.67; p<0.001).