Pharmacokinetics of teicoplanin in patients undergoing continuous blood purification therapy Adsorption of teicoplanin on PMMA and PS membrane, in vitro investigation / 持続的血液浄化法におけるテイコプラニンの薬物動態変化 ポリメチルメタクリレート膜・ポリスルホン膜での吸着率の比較検討
- Resource Type
- Journal Article
- Authors
- Harushi Niu; Hiroshi Miyawaki; Junichi Michikoshi; Toshiyuki Irie; 丹生 治司; 入江 利行; 宮脇 宏; 道越 淳一
- Source
- 日本急性血液浄化学会雑誌 / Journal of Japan Society for Blood Purification in Critical Care. 2012, 3(1):25
- Subject
- Adsorption of teicoplanin
CBP
PMMA
PMMA膜
PS
PS膜
テイコプラニンの吸着
持続的血液浄化法(CBP)
- Language
- Japanese
- ISSN
- 2185-1085
2434-219X
Teicoplanin has been considered to be non-dialyzable and non-filterable due to its high protein binding. This study was performed to evaluate the pharmacokinetics of teicoplanin during continuous blood purification therapy using polysulfone (PS) and polymethylmethacrylate (PMMA) membrane. As a result, Teicoplanin was cleared much more rapidly from the blood by adsorption of PS and PMMA membrane. We recommend obligatory drug monitoring to achieve therapeutic plasma concentrations.