Because elastic modulus is greatly different, as for many artificial joints using metal materials, mechanical mismatch occurs between bone. Therefore we aim at the realization of the artificial joint material having mechanical characteristics of the bone to solve the mechanical mismatch between bone and the artificial joint. In this report as the basic research, we examined the compression characteristic of titanium alloy-resin composite with the macro-heterostructure to suggest as an artificial joint material. The macro-heterostructure of the specimen was obtained by topological optimization based on the finite element analysis. We aimed at the optimization so that three axial elastic property of the cube specimen was different. The shape data of the macroheterostructure obtained by structure optimization is converted it into 3D-CAD data and molded three dimensions. The molding laminated powder of the titanium alloy (Ti-6Al-4V) in electron beam. The specimen poured epoxy resin into porous material of the titanium alloy and made it decrypted. We performed a simple uniaxial compression test using the specimen. The tendency of load-stroke curve scarcely changed in each axis of X, Y and Z direction. The elastic modulus calculated by face to measure strain was greatly different in the compression of the same axial direction.