A 61-year-old man underwent colonoscopy. A submucosal tumor, 0.8 cm in size, with an irregular surface was observed in the cecum. The submucosal tumor, 0.5 cm in size, had a smooth surface eight months ago. Colonoscopic polypectomy was performed because the size and shape of tumor had changed. By studying the polypectomized specimen, it was found that the tumor was in the submucosa with clear margin measuring 0.8×0.4 cm and was completely removed. Histological examination showed that the tumor was a Antoni type A neuroma. Only 33 cases of neuromas of the colo-rectum have been reported to date in Japan, none of which was resected endoscopically. Our present case was the first one in Japan, which was resected endoscopically.