Japanese Black beef farms in Miyagi Prefecture introduced Kedaka Japanese Black breeding cattle from every region of the country. These breeding cattle improved meat production of their offspring, however, it also spread damage by gastrointestinal nematodes (GIN) such as Strongyloides papillosus (SPL). Although grazed Holstein calves in Miyagi Prefecture received preventive measures for piroplasmosis, there had been almost no controlling strategies for GIN parasites, which might have caused delayed growth and poor reproductive performance. We examined various anthelmintic programs of avermectin derivatives in regard to the effectiveness of GIN control and the improvement of productivity. Two Japanese Black breeding farms in a different environmental condition were used as described in Trial 1 and 2. Trial 2 describes experiment with selected a Japanese Black breeding farm, where pregnant cattle were grazed. Results were compared between before and after experiment in a selected each farm. Ivermectin [Ivomec topical (IVMT), Merial Japan] was used as the anthelmintic. This was administered for both experiments at 0.1 mℓ/kg B.W. (1) single administration to dam one month before calving, (2) two administrations to calves; once at 1 month and the other at 6 months of age. This dosage regimen in Trial 1 and 2 demonstrated; Decrease in incidence of diseases, treatment frequency, and cost of treatment. 2) Reduction in open period as well as the number of artificial insemination per pregnancy. 3) Improvement in marketing weight as well as daily gain in trial farm. 4) Improvement in body height at 3 and 4 months of age. 5) Increase in serum albumin. Trial 3 examined the anthelmintic program conducted at a grazing farm for Holstein rearing cattle. As an anthelmintic, IVMT was used for 2008 and 2009. In 2010 eprinomectin [ Eprinex Tropical (EPNT, Merial Japan)] was used and cattle were divided into groups in the same manner as for IVMT. The time for EPNT administration was chosen based on the results of previous two couple of years’ experiments as well as calculated PARABAN value developed by Merial Japan. The results were compared with previous anthelmintic programs. The investigation of parasite eggs conducted November, 2010, there were decreases in detection rate and eggs per gram of GIN, and unidentified nematodes. In addition there were improvements in daily gain and reproductive performance such as the age of the first artificial insemination. In the blood test, hematocrit value, serum albumin and glucose increased in 2010 compared with two couple of previous years. The results described in trial 1, 2, and 3 proved that IVMT administration for Japanese Black kept inside barns could demonstrate reduced infection of SPL and Trichuris discolor as well as improved productivity. These results suggested that selection of anthelmintic drug should consider the species of nematodes and the environmental condition in order to maximize anthelmintic effect. Anthelmintic administration to rearing cattle improved weight gain, body height, and reproductive performance. Their serum albumin increased when they were examined at older than 150 days of age. Elimination or reduction of gastrointestinal parasites could improve overall physiological condition of cattle.