A 60-year-old man was diagnosed with necrotizing fasciitis of right lower extremity due to group A streptococcus and septic shock. After debridement, he pulled out of shock, but later developed cytomegalovirus enteritis. Administration of antiviral drugs was started, however there was no improvement, leading to multiple organ failure and deteriorated to death. In recent years, it has been widely accepted that septic patients suffer from immune paralysis which is caused by apoptosis of immunocompetent cells. And also, even if the acute phase resuscitation is successful, secondary infection may relapse. Although early detection and treatment for cytomegalovirus infection is most important, countermeasures against immunodeficiency, i.e., immune enhancing therapies, could be a breakthrough for the treatment of immunosuppressive sepsis.