The purpose of this study was to investigate the effects of mother and therapist vocalizations on children's neural activity with a psychomotor developmental disorder in rehabilitation situations, in order to clarify what kind of emotional effects different vocalizations of "others" have and how they affect rehabilitation intervention. A total of 9 conditions were set to 7 subjects (mean age: 4.9±2.9 years), 8 conditions for mother and therapist voice contact, and 1 condition for therapist only, in the actual rehabilitation situation, and the cranial neural activity between each condition was compared. The results showed that mother vocalizations showed brain activity in affective, motor, and cognitive regions, while therapist vocalizations showed brain activity in the linguistic region. Results suggest that mother and therapist's well-timed vocalizations can be an effective and efficient factor in supporting rehabilitation in terms of positive emotion and cognition changes, in addition to being a stimulus to promote therapeutic effects, which has already been shown to be a fundamental element in motor learning.