The purpose of this study is to analyze the combined effects of factors influencing the industry-research collaborative behavior of researchers at public research institutes. We found factors influencing industry-research collaborative behavior through literature review and established a conceptual model to analyze the interaction effects of these factors. Data for analysis were collected by conducting a survey targeting researchers at public research institutes in Daedeok Innopolis. Fuzzy-set qualitative comparative analysis (fsQCA) was used for data analysis. In the fsQCA results, it was found that the configuration with high social orientation, innovation orientation, creative self-efficacy and internal network increases the industry-research collaborative behavior. In addition, it was found that configuration with high social orientation, innovation orientation, creative self-efficacy, and external network increases the industry-research collaborative behavior. Finally, configuration with high social orientation, innovation orientation and government support but low level of creative self-efficacy and external network was found to increase industry-research collaborative behavior. This study is academically meaningful in that it analyzed the effect of combining social orientation, innovation orientation, creative self-efficacy, internal network, external network and government support on industry-research collaborative behavior using fsQCA. On the other hand, since social orientation and innovation orientation are important factors that affect industry-research collaborative behavior in combination with other factors, policies to improve them are required.