This study was attempted to determine the effect of premenstrual syndrome, menstrual pain, attitudes toward menstruation, and quality of sleep on learning immersion in female college students. The subjects of the study were 166 female college students at C University in Gyeongsangnam-do, and data collection was conducted from July 01 to August 31, 2023, using a Google questionnaire. The collected data were analyzed by correlation, multiple regression analysis. Premenstrual syndrome had a significant positive correlation with attitudes toward menstruation(r=.40, p<.001) and menstrual pain(r=.33, p<.001). And sleep quality had a significant positive correlation with menstrual pain(r=.31, p<.001) and learning immersion(r=.24, p=.002). Variables that have a significant impact on learning immersion include ‘irregularity in eating’ (β =.20, p=.007), ‘abdominal massage’ to relieve menstrual pain (β=.27, p=.003), and sleep quality (β=.16, p=.038). ‘Abdominal massage’ to relieve menstrual pain was found to be the best predictor of learning immersion, followed by ‘irregularity in eating’ and sleep quality. The total explanatory power was 13.9%. Based on the above results, in order to increase learning commitment through mitigation of premenstrual syndrome, education is necessary to seek active countermeasures by increasing various treatments and interest in them, and to have a positive attitude toward menstruation by having proper eating habits.