The domestic patient rights movement, which began in the 2000s, is accelerating further with the formation of a large coalition in 2010 of patient groups called the Korea Alliance of Patient Organization. As a result, the organization’s media activities, such as distribution of press releases, and the coverage of those activities by the media now play an important role in informing our society of the various issues affecting patients. However, the intent of those press releases and contents of media articles covering them are bound to differ in that the media selects only specific issues they want to cover from the content provided in the press releases. Therefore, in this study, 262 press releases distributed over the 12 years since the foundation of the Korea Alliance of Patient Organization and 210 press articles published by 13 media were analyzed to determine differences. To this end, this study employed the Topic Modeling technique, a big data research method and differences were identified in their purpose, attitude and approach. This study suggest patient organizations’ media communication strategies, and help the public to better understand patients, patient groups, and the media.