This study is a descriptive research study to analyze factors affecting patient safety management activities by identifying shared leadership, organizational communication, and nursing service perceived by nurses to prepare basic data for theoretical and practical information and intervention measures. This study collected data from 155 clinical nurses in C region in G-do from July 17 to July 28, 2023, and a total of 154 copies were finally analyzed. Using the SPSS Win. 25.0 program, technical statistics, t-test, one-way ANOVA, Pearson correlation coefficient, and hierarchical multiple regression were analyzed. As a result of analyzing variables affecting the subject's patient safety management activities with multiple regression using hierarchical selection, the higher the shared leadership, the higher the patient safety management. In order to efficiently perform nursing for nurses' patient safety management activities, research should be continuously conducted to develop specific intervention programs that can support patient safety nursing activities and verify their effectiveness