Discovery and biological evaluation of potent, selective, orally bioavailable, pyrazine-based blockers of the Na v1.8 sodium channel with efficacy in a model of neuropathic pain
Resource Type
Article
Authors
Scanio, Marc J.C. ; Shi, Lei ; Drizin, Irene ; Gregg, Robert J. ; Atkinson, Robert N. ; Thomas, James B. ; Johnson, Matthew S. ; Chapman, Mark L. ; Liu, Dong ; Krambis, Michael J. ; Liu, Yi ; Shieh, Char-Chang ; Zhang, XuFeng ; Simler, Gricelda H. ; Joshi, Shailen ; Honore, Prisca ; Marsh, Kennan C. ; Knox, Alison ; Werness, Stephen ; Antonio, Brett ; Krafte, Douglas S. ; Jarvis, Michael F. ; Faltynek, Connie R. ; Marron, Brian E. ; Kort, Michael E.
Source
In Bioorganic & Medicinal Chemistry 2010 18(22):7816-7825
Subject
Language
ISSN
0968-0896