An Engineering-Optimized Cardiac Pacemaker by Manipulating Na+/Ca2+ Exchange Current and Na+/K+ Pumping Current
- Resource Type
- Conference
- Authors
- Li, Yacong; Wang, Kuanquan; Li, Qince; Luo, Cunjin; Zhao, Na; Liu, Yizhou; Zhang, Henggui
- Source
- 2019 Computing in Cardiology (CinC) Computing in Cardiology (CinC), 2019. :Page 1-Page 4 Sep, 2019
- Subject
- Bioengineering
Computing and Processing
Signal Processing and Analysis
Pacemakers
Cells (biology)
Biological system modeling
Calcium
Stem cells
Avalanche photodiodes
- Language
- ISSN
- 2325-887X
Biological pacemaker is a possible therapy for arrhythmias but there are several problems when creating single pacemaker cells based on ventricular myocytes by inhibiting inward rectifier current (I K1 ) and combining hyperpolarization-activated funny channel current (I f ), such as the change of intracellular concentration equilibrium and un-physiological pacing frequency. Previous biological studies suggested that Na + -Ca 2+ exchange current (I NaCa ) -related gene increased 4-fold in pacemaker cells than normal cardiac myocytes. In addition, the accumulation of intracellular Na + was observed due to the combination of I f and prompting feedback mechanism of Na + /K + pumping may accelerate pumping out excessive Na + in pacemaker cells. In this study, we construct a pacemaker model based on a ventricular myocyte model by manipulating I K1 and I f and optimize this pacemaker model by augmenting I NaCa and I NaK . Simulating results showed that overexpressing I NaCa and I NaK balanced the equilibrium of intracellular ionic concentrations effectively and enhanced the pacemaking ability. And the most optimized cooperation between I NaCa and I NaK was defined in this study. The action of I f in pacemaker even changed in optimized model and the deep reason is illustrated in detailed. This study might guide the clinical research of biological pacemaker.