Compartmental modeling in dynamic SPET using projection data
- Resource Type
- Conference
- Authors
- Karjalainen, P.A.; Vauhkonen, M.; Kaipio, J.P.
- Source
- Proceedings of the 20th Annual International Conference of the IEEE Engineering in Medicine and Biology Society. Vol.20 Biomedical Engineering Towards the Year 2000 and Beyond (Cat. No.98CH36286) Engineering in medicine and biology 1998 Engineering in Medicine and Biology Society, 1998. Proceedings of the 20th Annual International Conference of the IEEE. 2:763-766 vol.2 1998
- Subject
- Bioengineering
Image reconstruction
Vectors
Kalman filters
Least squares methods
Tomography
Physics
Recursive estimation
Transportation
Reconstruction algorithms
Time measurement
- Language
- ISSN
- 1094-687X
A method for compartmental modeling in dynamic SPET studies is proposed. The method is based on direct use of projection data and does not necessitate the reconstruction of the SPET images. The activity is modeled with the first order Markov model and the Kalman smoothing algorithm is used for the recursive estimation of the activities. The transportation coefficients are simultaneously estimated using a nonlinear output least squares method. The method is evaluated using simulations.