In order to improve the voltage control accuracy of AVC system and reduce time-consuming, a new voltage control strategy of AVC system based on data mining is proposed in this paper. The fuzzy c-means clustering mining method is used to mine the voltage data of AVC system to obtain the key voltage parameters. On this basis, taking the minimum active power loss of AVC system as the goal, the voltage control objective function of AVC system is constructed. Under the constraints, the objective function is solved to complete the voltage control. The experimental results show that compared with the traditional control method, the control accuracy of this method is higher and the control time is shorter.