Air-defense command and decision system is a distributed, heterogeneous, loosely coupled, and complex artificial intelligent control system. Collaborative decision-making based on multi-agent system is an effective way to achieve joint operational command and control system. By studying the traditional combat simulation model, a coordinated operation decision model was proposed based on multi-agent, and the intelligent air-defense decision support system framework was given. Finally, the adaptability and decision-making efficiency of the decision-making model in real-time combat environment were analyzed.