An artificial intelligence wireless stimulating system-on-chip (AIWSSoC) is proposed in this study. The AIWSSoC integrates two EEG monitoring channels, wireless interface and charging, a UART interface, an epilepsy detection algorithm, a power management circuit, an electrical stimulation circuit, and an optogenetic stimulation controller into a chip. Moreover, the AIWSSoC functions as a seizure suppressor with an off-chip device. Animal experimental result verifies the function of recording and different types of electrical stimulations.