Dual Ion-Selective Membrane Deposited Ion-Sensitive Field-Effect Transistor (DISM-ISFET) Integrating Whole Blood Processing Microchamber for In Situ Blood Ion Testing
- Resource Type
- Conference
- Authors
- Chen, Xiao-Wen; Huang, Syuan-Rong; Huang, Nien-Tsu
- Source
- 2023 IEEE 36th International Conference on Micro Electro Mechanical Systems (MEMS) Micro Electro Mechanical Systems (MEMS), 2023 IEEE 36th International Conference on. :1021-1024 Jan, 2023
- Subject
- Bioengineering
Components, Circuits, Devices and Systems
Fields, Waves and Electromagnetics
Photonics and Electrooptics
Power, Energy and Industry Applications
Sensitivity
Ions
Feature extraction
Sensors
System-on-chip
Transistors
Blood
blood ion concentration test
ion-selective membrane (ISM)
ion-sensitive field-effect transistor (ISFET)
- Language
- ISSN
- 2160-1968
Blood ion testing is one of the methods that is commonly used as of monitoring immune status and providing lots of physiological information for disease diagnosis. We proposed a microfluidic device integrating dual ion-selective membranes and dual-gate ion-sensitive field-effect transistor (DISM-ISFET) for whole blood processing and blood ion concentrations monitoring. In this system, the Anti-D-coated trench array and filter membrane embedded microchamber greatly shorten the serum extraction time to 4 min. Besides, the DISM-ISFET array sensor enables simultaneous Na+ and K+ ion sensing in 10 min. The above features make this fully integrated and portable system a rapid and sensitive tool for in situ blood ion concentration diagnosis.