This article presents a comparative study of two topologies of three-phase photovoltaic inverters connected to the grid, between the usual two-level inverter and three-level NPC (Neutral Point Clamped) inverter. Inverter control and the boost converter MPPT controller are based on the SRF-dq method and the INC algorithm respectively. The comparison relies on evaluating the overall efficiency and harmonic distortion of the inverter. All circuits are modeled and simulated using Matlab-Simulink. The results obtained indicate satisfaction with the quality, of the current and voltage injected into the electrical grid, and reflect that both inverters are efficient and comply with IEEE-519 standard recommendations, but the three-level inverter performs better results than the two-level inverter.