This paper explores asynchronous FIFOs design choices, more specifically FIFOs from the quasi-delay insensitive (QDI) template family. It proposes eight different asynchronous FIFO structures on a CMOS 45nm technology, using a QDI standard cell library. Structures are exercised through analog-mixed-signal simulation, ranging from nominal to subthreshold supply voltages. Follows a comparison of area, throughput and power efficiency. The experimental results allow inferring a technique for designers to select the most adequate QDI FIFO flavor for specific circuits. Insight on the experiments assesses the beneficial and/or limiting effects of using the specific cell library.