This paper proposes a high reliability relay protection configuration and setting scheme for distribution network. The system includes protection configuration, value setting method and protection cooperation. The outlet circuit breaker and the contact switch in the substation are equipped with current limiting protection devices in case of inter-phase short-circuit fault, the outlet circuit breaker current limiting protection devices can limit the current quickly. If the fault is permanent, a current limiting protection device can be configured on the contact switch to isolate the faulty area and restore power supply to the healthy area under current limiting conditions. The simulation results show that the proposed protection configuration scheme can improve the rapidity, selectivity and power supply reliability of distribution network protection. The algorithm has wide applicability and high application value.