In cooperative air-defense operations of the naval fleet, the formation of the relay guidance scheme is a prerequisite for the implementation of the relay guidance. In view of the characteristics of relay guidance operation, the generation problem of relay guidance program is transformed into a multi-platform collaborative decision-making problem. Based on the analysis of the relay guidance operation process, the concept of collaborative decision-making in relay guidance is put forward, and the basic process of collaborative decision-making is given. Then, the key technology of collaborative decision-making is described. This research provides thereby decision support for the formation of the relay guidance scheme, and which supplies technical support for the capability form of ship-to-air missile relay guidance.