Landmine and improvised explosive (IED) are the major threat to the occupants inside armored vehicles. IED-detonation introduced Global effects of severe acceleration can greatly hurt vehicle occupants. To investigate the responses of armored vehicle and its occupants subjected to landmine explosion, an low-cost equivalent miniature model of the vehicle replacing real-scale one was built. With a full scale finite element models using HyperMesh software, the miniatures shows similar results as its actual model. The fluid and structure coupled algorithm successfully simulated the phenomena of armored vehicle subjected to landmine. Finally, a MEMS sensor-based experimental setup was employed to monitor vehicle occupant during IED explosion, and its experimental result was in accordance with simulation.