Conventional Positron Emission Tomography (PET) and Single Photon Emission Tomography (SPECT) scanners are usually built using multiple detectors placed in a cylindrical geometry leading to both transaxial and axial gaps between detectors. These undesired gaps decrease system’s sensitivity and degrade spatial resolution towards the edges of the detector. To reduce gaps, we propose to construct a dedicated-breast PET made out of 14 curved LYSO crystals glued together using a high refractive coupling media (n=1.7). The aims of the current work are: i) to reduce edge effects when using glued crystals, and ii) to show the feasibility of the proposed edge-less PET system.We have glued the lateral sides of two cuboid LYSO crystals (n=1.81) of 33.0×25.4×10.0 mm 3 using Meltmount (n=1.7)and acquired data moving a 22 Na pencil beam (~450 µm slit) along the x- and y-axes. Results were compared with the standard case in which the lateral sides are black painted and keep an air gap (0.4 mm) in between the two blocks. The photon interaction coordinates were estimated using a Neural Network (NN) and, the detector performance was evaluated using the mean average error (MAE) parameter. Additionally, we show the design details of a system based on 14 LYSO curved crystals coupled to 12×12 SiPM arrays mounted on a custom flexible board containing also the readout electronics. We have experimentally acquired data and we also simulated (GATE/Geant4 platform) a back-to-back source at the center of the Field of View (cFOV). Data was reconstructed using MLEM with 4 iterations and a voxel size of 0.5 mm.Results show that gluing scintillation crystals with a high refractive index compound and using NN for impact position determination reduces edge effects, achieving spatial resolution of 0.7 mm from the simulated back-to-back source at the cFOV.