The orchestration and management of 5G network slicing (NS) requires cross-domain orchestration across 5G radio access network (RAN), 5G core network (CN), and transport network and also coordination of closed loops of each 5G network segment. We propose a resource orchestration and management architecture for end-to-end (E2E) 5G network slices to automate the flexible and high-performance NS’s management and orchestration. Through developing a prototype of the proposed architecture on an experimental 5G network, the effectiveness of our architecture is proven through prominent use cases certified by ETSI ZSM.