An integrated nanoplasmonic biosensor for monitoring cytokine secretion from single cells
- Resource Type
- Conference
- Authors
- Li, Xiaokang; Soler, Maria; Szydzik, Crispin; Khoshmanesh, Khashayar; Schmidt, Julien; Yesilkoy, Filiz; Belushkin, Alexander; Coukos, George; Mitchell, Arnan; Altug, Hatice
- Source
- 2019 15th Conference on Ph.D Research in Microelectronics and Electronics (PRIME) Ph.D Research in Microelectronics and Electronics (PRIME), 2019 15th Conference on. :113-116 Jul, 2019
- Subject
- Aerospace
Bioengineering
Communication, Networking and Broadcast Technologies
Components, Circuits, Devices and Systems
Engineered Materials, Dielectrics and Plasmas
Power, Energy and Industry Applications
Signal Processing and Analysis
Biosensors
Microfluidics
Nanobioscience
Real-time systems
Fabrication
Monitoring
Biomembranes
label-free
nanoplasmonics
single-cell analysis
microfluidics
- Language
An innovative nanoplasmonic biosensor was presented for real-time label-free monitoring of cytokine secretion at single-cell resolution. This biosensor is integrated with a uniquely designed microfluidic device that provides a microchamber for cell incubation and fluid regulation for stable live cell monitoring. Different spatiotemporal profiles of interleukin-2 secretion were observed from single lymphoma cells. This novel configuration of label-free biosensor is promising for single-cell related studies.