MHz ultrasonic drive-in: Localized drug delivery for osteoarthritis therapy
- Resource Type
- Conference
- Authors
- Nieminen, Heikki J.; Salmi, Ari; Rinta-aho, Jari; Hubbel, Geoffrey; Wjuga, Kimmo; Suuronen, Jussi-Petteri; Serimaa, Ritva; Haeggstrom, Edward
- Source
- 2013 IEEE International Ultrasonics Symposium (IUS) Ultrasonics Symposium (IUS), 2013 IEEE International. :619-622 Jul, 2013
- Subject
- Fields, Waves and Electromagnetics
Ultrasonic imaging
Shock waves
Acoustics
Lasers
Joints
Imaging
Drugs
drug delivery
high intensity focused ultrasound
laser-ultrasound
articular cartilage
osteoarthritis
- Language
- ISSN
- 1051-0117
Osteoarthritis (OA) is a significant musculoskeletal disease with no cure. Current drug delivery techniques feature poor spatial localization (systemic delivery or injection into the synovial capsule). We previously used kHz high-intensity ultrasound to deliver micro- and nano-particles into articular cartilage (AC). Here we investigated whether MHz ultrasound can deliver particles into AC. Using high-intensity focused ultrasound (HIFU) we drove agents into 45% depth of the AC thickness. In addition, laser-induced shock waves showed drive-in effect. Our results demonstrate that MHz ultrasound can locally administer agents into AC. The technique could potentially be used for localized OA drug therapy.