In order to transmit multi-constrained QoS multimedia flows with large scale data and information, such as image, voice and video etc., multi-constrained QoS path selection is a big challenge and a key problem need to be resolved urgently for WMSN. In this paper a novel multi-constrained QoS path selection scheme based on enhanced simulated annealing is proposed and a more refined cooling schedule is constructed while two key factors, attenuation function of control parameter T and termination value of T were concerned. Furthermore, the influence of some classical random generators on the algorithms performance is investigated. Theoretical analysis and experiment results demonstrate that the proposed method, which can greatly enhance the quality of final configuration while not sacrificing the algorithm complexity, is an effective multi-constrained QoS path selection algorithm showing better performance than the other pertinent algorithms.