Towards rapid high-resolution mid-IR imaging for molecular spectral histopathological diagnosis of oesophageal cancers
- Resource Type
- Conference
- Authors
- Hermes, M.; Nallala, J.; Huot, L.; Tomko, Jan; Junaid, S.; Tidemand-Lichtenberg, P.; Pedersen, C.; Stone, N.
- Source
- 2017 Conference on Lasers and Electro-Optics Europe & European Quantum Electronics Conference (CLEO/Europe-EQEC) Lasers and Electro-Optics Europe & European Quantum Electronics Conference (CLEO/Europe-EQEC, 2017 Conference on). :1-1 Jun, 2017
- Subject
- Bioengineering
Communication, Networking and Broadcast Technologies
Components, Circuits, Devices and Systems
Computing and Processing
Engineered Materials, Dielectrics and Plasmas
Engineering Profession
General Topics for Engineers
Photonics and Electrooptics
Quantum cascade lasers
Cancer
Biomedical imaging
Physics
Light sources
- Language
Modem western societies suffer from diseases of civilization which are mainly associated with smoking, fatty diets and obesity. One of those is the Gastroesophageal reflux disease (GERD) often also loosely called heartburn. GERD can in some cases lead to an abnormal change of cells (metaplasia) in the lining of the oesophagus. This syndrome is defined as Barrett's oesophagus (BO). If the oesophagus suffers from reflux of acid (heartburn) it can protect itself by replacing the normal stratified squamous epithelium by acid resistant columnar epithelium with goblet cells usually found lower in the gastrointestinal tract. These cells growing in an area where they usually do not belong, have a significantly higher risk to degenerate into cancers. These conditions are evaluated by performing endoscopy with harvest of biopsies. Biopsies are then cut and stained with haematoxylin and eosin and assessed by a pathologist. Patients diagnosed with BO undergo a regular surveillance in order to monitor if the metaplasia progresses into dysplasia or adenocarcinoma.